Use of

Hyperthermia - cancer treatment

Hyperthermia is a procedure in which the tumor tissue is heated from outside to a temperature of 38 - 42 degrees Celsius. This change of temperature leads to a shortage of oxygen and nutrients in the tumor. Then there is the acidification of the heated cells and a disruption of cell metabolism, which may result in self-destruction (apoptosis) of the tumor. More importantly, the elevated temperature does not damage healthy cells.

The therapeutic effect of hyperthermia is based on the strengthening of some of the mechanisms of immune system. A side effect of chemotherapy is often weakness of the body and its immune system. For many patients, hyperthermia can compensate for this side effect by running additional processes of self-defense of the body. One of the most important of these processes is activation of NK cells (Natural Killer). These cells are produced in the human body and its mission is to destroy other cells recognized by NK as hostile - to eliminate. NK cells are activated to the activities by a particular type of protein Hsp70 (Heat Shock Protein). This protein occurs selectively on the surface of human cancer cells but not on the surface of healthy cells. NK cells activated by TKD (Hsp70 peptide) / IL-2 (interleukin 2) damages the tumor encased in a membrane of Hsp70 protein. To this type of NK cells included lymphocytes T, such as CD8 +. There are extensive reports that infiltration of lymphocytes into the tumor tissues is essential for the inhibition of cancer and has a positive influence on the forecast for treating multiple types of cancer. Numerous studies indicate that the CD8 + lymphocytes infiltration into tumor micro-environment is favorable to the immunological mechanism for patients. CD8 + are able to directly kill cancerous cells. When CD8 + is subjected to the action of a  moderate hyperthermia (39.5 ° C), is an increase in antigen production of IFN and damage to the cancer cells as compared to the conditions of lower temperatures.

Hyperthermia is an adjunct to cancer therapy. It is used primarily in combination with chemotherapy, radiotherapy and chemo-radiotherapy. Because of the demonstrated base of biological interaction (both in combination with most of cytostatics and ionizing radiation) and lack of toxicity, hyperthermia benefits from the application may feel each patient with cancer. It is used in all advanced tumors, as well as in metastases and relapses. Good results as well are achieved using of hyperthermia in the palliative treatment. In patients who have already received the maximum dose of a conventional therapies, it is a noticeable positive effect even in the usual treatment of pain.

 

Other applications of hyperthermia

Currently hyperthermia is also used to treat non-oncological diseases such as:

  • Hypertension
  • Arthritis
  • Chronic back pain
  • Neuralgia resistant to therapy
  • Migraines
  • Subacute chronic inflammation
  • Rheumatic diseases (degenerative and inflammatory states subacute)
  • Ankylosing spondylitis (Bechterew's disease)
  • Systemic scleroderma
  • Atopic dermatitis
  • Seasonal affective disorder (SAD)

Hypertension
Studies conducted in 1989-1993 revealed that cyclic application of the moderate whole-body hyperthermia, effectively reduce excessive blood pressure: systolic pressure drops an average of 22 mmHg and diastolic blood pressure decreases by 12 mm Hg, without any adverse effects with clinical significance.

Schemes of whole body hyperthermia treatments for selected non-oncological indications

No.

Indication

Target

temp.

Phases of heating

Number of sessions

(in standard treatment)

Monitoring

Comments

rising temp.

(first 15 min. on 100% power)

constant temp.

(plateau phase)

maintain temp.

(rest after treatment)

ºC
min. min. min.

1

Hypertension

38,3

30

0

30

8 (2 x week)
or
8 (every other day)

T(the armpit)
Pulse

Systolic pressure strzalka by 22 mmHg,
diastolic pressure strzalka by 12 mmHg
10% no answer

2

Chronic back pain

38,5

45

15

30

7 (1 x week)

T(rectum)
T(the armpit)
Pulse

Intake of painkillers after one year <10%

3

Fibromyalgia syndrome

38,1

40

15

30

6 (2 x week)
or  6 (every other day)
or  6 days in a row

T(the armpit)
Pulse

After 6 months 20% of patinets feel less pain, than before treatment according to „F.I.Q”

4

Psoriatic arthritis (Psoriasisarthritis)

38,5

45

15

30

6 (in 8 days)
or
6 days in a row

T(rectum)
T(the armpit)
Pulse

  • easing the pain;
  • significant deacrease of DAS28 (Disease Activity Score 28) over 3 months

5

Arthritis of the spine occupation

38

30

15

120

(lying down)

6 (2 x week)

T(the armpit)
Pulse

  • easing the pain over 3 months

6

Ankylosing spondylitis

38,5

45

15

30

6 (in 8 days)
or
6 days in a row

T(rectum)
T(the armpit)
Pulse

  • easing the pain
  • less disease activity index
  • erythrocyte sedimentation rate over 3 months.

7

Systemic sclerosis

38,3

30

0

30

15 (2 x week)
or
15 (every other day)

T(the armpit)
Pulse

50% of patients followed over two years decrease in the number and intensity of the symptoms of Raynaud's

Source: Von Ardenne Institut elaboration

Bibliography

Ad. 1

* Mischke M. Wirkungen einer einmaligen bzw. seriellen Infrarot-A-Hyperthermie bei Patienten mit artrieller Hypertonie der WHO-Stadien I und II.

Diss. Humboldt-Universität Berlin 18.07.1991

* Meffert H, Scherf HP, Meffert B. Milde Infrarot-A-Hyperthermie: Auswirkungen von Serienbestrahlungen mit wassergefilterter Infrarotstrahlung auf Gesunde und Kranke mit arterieller Hypertonie bzw. systemischer Sklerodermie. Akt Dermatol, 1993; 19:142-148

Ad. 2

* Weller E, Ulrlich D. Infrarot-A-Hyperthermie-Anwendung bei Patienten mit Analgetica-Abusus wegen chronischer Rücken-schmerzen. Vortrag auf dem 95.

Kongreß der Gesellschaft für Phys Med. und Rehab

5.10.1990

Ad. 3

* Brockow T, Wagner A, Franke A, Offenbächer M, Resch KL. A Randomized Controlled Trial on the Effectiveness of Mild Water-filtered Near Infrared Whole-body Hyperthermia as an Adjunct to a Standard Multimodal Rehabilitation in the treatment of Fibromyalgia. Clin J Pain 2007; 1:67-75

* Waltz J, Hinzmann J, Haase I, Witte T.

Ganzkörperhyperthermie In der Schmerztherapie – eine kontrollierte Studie an Patienten mit Fybromyalgiesyndrom. Schmerz 2013; 1:38-45

* Schleenbecker HG, Schmidt KL. Zur Wirkung einer iterativen milden Ganzkörperhyperthermie auf den Fibromyalgieschmerz. Phys. Rehab. Kur Med., 1998; 8:117-117 

Ad. 4

* Schwab F. Wirkung iterativer Ganzkörperhyperthermie mit wassergefilterter Infrarot-A-Strahlung auf funktionelle und funktionale Parameter der Gesundheit sowie proinflammatiorische Zytokine bei Arthritis psoriatica. Inauguraldiss. Justus-Liebig-Universität

Gießen, Internist.Rheumatol. 03.04.2012

Ad. 5

* Stegemann I, Hinzmann J, Haase I, Witte T. Evaluation der ganz-körperhyperthermie mit wassergefilterter Infrarot-A-Strahlung in der Therapie von Schmerzen bei Patienten mit Spondyloarthritis.

22. Rehawissenschaftl. Kolloquium

4.-6.3.2013:384f

Ad. 6

* Neumann S. Wirkung iterativer Ganzkörperhyperthermie mit wassergefilterter Infrarot-A-Strahlung auf funktionelle und funktionale Parameter der Gesundheit sowie proinflammatiorische Zytokine bei Arthritis psoriatica. Inauguraldiss. Justus-Liebig-Universität

Gießen, Internist.Rheumatol. Einreichung Herbst 2013

Ad. 7

* Meffert H, Scherf HP, Meffert B. Milde Infrarot-A-Hyperthermie: Auswirkungen von Serienbestrahlungen mit wassergefilterter Infra-rotstrahlung auf Gesunde Und Kranke mit arterieller Hypertonie bzw. systemischer Sklerodemie. Akt Dermatol, 1993; 19:142-148

* Förster J, Fleischanderl S, Wittstock S, Storch A, Meffert H. Letter to the Editor: Infrared-Mediated Hyperthermia is Effective In the Treatment od Scleroderma-Associated Raynaudd’s Phenmomenon.

J Investig Dermatol, 2005; 6:1313-16